Email this article CYTOKINE PROFILE OF BLOOD SERUM IN ACUTE PYELONEPHRITIS AT DIFFERENT TRIMESTERS OF GESTATION
- Authors: Kholimenko I.M.1, Shatokhin M.N.2, Konoplya A.A.3, Evsegneeva I.V.4, Mavrin M.Y.2
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Affiliations:
- Regional budgetary healthcare institution "Kursk regional multidisciplinary clinical hospital" of the Ministry of Health of the Kursk region, Kursk, Russian Federation
- Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
- Limited Liability Company "STOMED" Medical center, Moscow, Russian Federation
- I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
- Section: ORIGINAL ARTICLES
- Submitted: 14.03.2025
- Accepted: 24.07.2025
- URL: https://rusimmun.ru/jour/article/view/17117
- DOI: https://doi.org/10.46235/1028-7221-17117-CPO
- ID: 17117
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Abstract
Abstract
Introduction. Among bacterial infections that pose a threat to the life and health of women, urinary tract infections occupy a leading position in the structure of reasons for hospitalization and the development of negative reactions during pregnancy. The fundamental importance for the onset and end of acute pyelonephritis is given to the state of the innate link of immunity. A special role is given to cytokines of various types in the formation of the “cytokine cascade”. The increase in the incidence of pyelonephritis in pregnant women shows insufficient awareness and lack of study, as well as a lack of understanding of all aspects of the pathogenesis of this disease, especially regarding the cytokine status of pregnant women at the local and systemic levels.
Research objective: to study the dynamics of the cytokine profile of peripheral blood plasma in acute pyelonephritis in different trimesters of pregnancy before and after treatment
Material and methods. The study included 143 women (mean age 25.3±5.2 years), divided into groups: comparison: healthy non-pregnant women and women with physiological pregnancy in the 1st, 2nd and 3rd trimesters without kidney pathology, main: pregnant women with acute serous pyelonephritis in the first, second and third trimesters of pregnancy, as well as two groups of women with acute pyelonephritis in the 2nd and 3rd trimesters of gestation with basic treatment without and including the immunomodulator Viferon. In the plasma of peripheral blood, the dynamics of changes in the cytokine profile before and after treatment were studied.
Results. In acute serous pyelonephritis in all trimesters of pregnancy, the cytokine content at the systemic level was increased, especially in the 2nd and 3rd trimesters, which indicates the presence of immune inflammation. The basic treatment does not fully normalize the altered parameters of the cytokine profile, mainly in the 2nd and 3rd trimesters of gestation. The best corrective effect is achieved by pharmacotherapy with the addition of Viferon to the basic treatment. The results of the work expand the existing understanding of the participation of cytokines in the pathogenesis of acute pyelonephritis in different trimesters of pregnancy.
About the authors
Ivan Mikhailovich Kholimenko
Regional budgetary healthcare institution "Kursk regional multidisciplinary clinical hospital" of the Ministry of Health of the Kursk region, Kursk, Russian Federation
Email: kholimenko@yandex.ru
ORCID iD: 0000-0003-2945-6821
SPIN-code: 6450-2444
Ph.D. in Medicine
Russian Federation, Kursk region, Kursk city, Sumskaya street 45a.Maxim Nikolaevich Shatokhin
Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Email: sh.77@mail.ru
ORCID iD: 0000-0002-1285-7357
SPIN-code: 7344-9309
Professor, Professor of the Department of Endoscopic Urology of Russian Medical Academy of Postgraduated Education
Russian Federation, 125993, Moscow, Russian Federation;Alexey Alexandrovich Konoplya
Limited Liability Company "STOMED" Medical center, Moscow, Russian Federation
Email: kanabis03101980@yandex.ru
ORCID iD: 0000-0001-5040-7499
SPIN-code: 2766-8468
Doctor of Medical Sciences, Associate Professor, Head of the Department of Obstetrics and Gynecology
Russian Federation, 140000, Moscow, Russian Federation;Irina Valentinovna Evsegneeva
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation
Email: ivevsegneeva@yandex.ru
ORCID iD: 0000-0002-6624-1363
SPIN-code: 6467-4120
Doctor of Medical Sciences, Professor, Department of Clinical Immunology and Allergology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University
Russian Federation, 119991, Moscow, Russian Federation.Mikhail Yuryevich Mavrin
Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Author for correspondence.
Email: dr.mavrin@mail.ru
ORCID iD: 0009-0003-2562-1495
SPIN-code: 7096-2610
Candidate of Medical Sciences. Urologist. Department of Endoscopic Urology, Federal State Budgetary Educational Institution of Higher Professional Education, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation;
Russian Federation, 125993, Moscow, Russian Federation;References
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