LEADING MECHANISMS OF IMMUNOPATHOGENESIS IN VARIOUS TYPES OF INFLAMMATION (INFECTIOUS, AUTOIMMUNE, ATOPIC)

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Abstract

The purpose of this study was to identify the leading mechanisms of immunopathogenesis of inflammation diseases of different genesis. Using the indirect immune fluorescence method, the number of lymphocytes carrying surface receptors CD3, CD4, CD8, CD16, CD56, CD20, CD72, mIgM, mIgG, CD23, CD25, CD71, HLA-DR, CD54, CD95, CD30, CD38, CD178. Lymphocytes of patients with aseptic inflammation showed an increase in the number of CD25, CD71, and HLA-DR lymphocytes – markers of activation. But the complete absence of lymphocyte activation was found in severe cases of infectious inflammatory process in patients with osteomyelitis. In autoimmune inflammation, the lymphocytes activation process has a high intensity and is accompanied by a weakening of the expression of the activation receptor apoptosis CD95. Atopic diseases (atopic dermatitis and atopic bronchial asthma) are characterized by an intense lymphocytes activation process, which is accompanies with a significant decrease in the number of CD95+ lymphocytes, but different by another lymphocytes subpopulations. 

About the authors

J. M. Salmasi

Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation

Author for correspondence.
Email: profjms@yandex.ru

PhD, MD (Medicine), Head of the Department of Pathophysiology and Clinical Pathophysiology, Faculty of Medicine,

Moscow

Russian Federation

G. V. Poryadin

Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, MD (Medicine), Corresponding Member, Russian Academy of Sciences, Professor, Department of Pathophysiology and Clinical Pathophysiology, Faculty of Medicine,

Moscow

Russian Federation

A. N. Kazimirsky

Federal State Budget Institution of Higher Education “Pirogov Russian National Research Medical University» Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, MD (Biology), Leading Researcher of the Department of Molecular Technologies,

Moscow

Russian Federation

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Copyright (c) 2019 Salmasi J.M., Poryadin G.V., Kazimirsky A.N.

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