Email this article HLA-DRB1* ASSOCIATIONS WITH SPORADIC SEPTAL CONGENITAL HEART DISEASES WITHOUT CHROMOSOMAL DISEASES
- Authors: Tsepokina A.V.1, Deev N.S.1,2, Shmulevich S.A.3, Shabaldin A.V.1,2, Korostelev A.A.3, Ponasenko A.V.1
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Affiliations:
- Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”
- Federal state budgetary educational institution of higher education “Kemerovo state medical University” of the Ministry of health of the Russian Federation
- State budgetary institution of health care “Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash”
- Issue: Vol 22, No 2-1 (2019)
- Pages: 617-619
- Section: ORIGINAL ARTICLES
- Submitted: 21.05.2020
- Accepted: 21.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/237
- DOI: https://doi.org/10.31857/S102872210006991-5
- ID: 237
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Abstract
Associations of HLA-DRB1* alleles were determined with sporadic septal congenital heart defects in children. 97 children (44 boys and 53 girls) with an isolated ventricular septal defect (VSD) without chromosomal diseases and anomalies were examined. Surveyed 132 healthy children (control group). The frequency of occurrence of 14 alleles of the HLA-DRB1 gene (01, 04, 07, 08, 09, 10, 11, 12, 13, 14, 15, 16, 17, 18). Mathematical processing was performed using the STATISTICA 8.0 application package (StatSoftInc., USA). It was revealed that in children with sporadic CHD without chromosomal diseases, HLA-DRB1*15 (p = 0.03) was signifi cantly more frequent in the genotype compared with the control group. The formation of sporadic septal congenital heart defects without chromosomal diseases is positively associated with HLA-DRB1*15.
About the authors
A. V. Tsepokina
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”
Author for correspondence.
Email: fake@neicon.ru
junior researcher of the laboratory of genomic medicine,
Moscow
Russian FederationN. S. Deev
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”;Federal state budgetary educational institution of higher education “Kemerovo state medical University” of the Ministry of health of the Russian Federation
Email: fake@neicon.ru
laboratory assistant-researcher of the laboratory of cellular technologies,
Moscow
Russian FederationS. A. Shmulevich
State budgetary institution of health care “Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash”
Email: fake@neicon.ru
PhD, head of children’s Department,
Moscow
Russian FederationA. V. Shabaldin
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”;Federal state budgetary educational institution of higher education “Kemerovo state medical University” of the Ministry of health of the Russian Federation
Email: weit2007@yandex.ru
M.D., leading researcher of laboratory of cell technologies,
Moscow
Russian FederationA. A. Korostelev
State budgetary institution of health care “Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash”
Email: fake@neicon.ru
M.D., professor of the Department of microbiology, immunology. virology,
Moscow
Russian FederationA. V. Ponasenko
Federal state budgetary scientific institution “Research Institute of complex problems of cardiovascular diseases”
Email: fake@neicon.ru
Ph.D., head of the Department of Genomic Medicine,
Moscow
Russian FederationReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).