Email this article THE EXPRESSION OF DIFFERENT ISOFORMS OF TGFβ AND ITS RECEPTORS IN UTERINE LEIOMIOMA
- Authors: Voronin D.N.1, Voskresenskaya D.L.1
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Affiliations:
- Federal State Budget Establishment “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova” of the Ministry of Health of Russia
- Issue: Vol 22, No 2-1 (2019)
- Pages: 190-191
- Section: ORIGINAL ARTICLES
- Submitted: 13.04.2020
- Accepted: 13.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/40
- DOI: https://doi.org/10.31857/S102872210006450-0
- ID: 40
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Abstract
The distinctive feature of the myomatous node tissue is the increased reception of TGFbeta. The main role in the activation of fi broblasts and their production of collagen I type in the myomatous node plays TGFbeta1, TGFbet2 and TGFbeta3. The higher level of synthesis and production of TGFbeta1 isoform in the nodes with large amount of collagen I type allow to suggest the leading role of this cytokine in the regulation of the intensity of fi brosis in the leiomyoma tissue.
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About the authors
D. N. Voronin
Federal State Budget Establishment “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova” of the Ministry of Health of Russia
Author for correspondence.
Email: niimid.immune@mail.ru
PhD, senior researcher of the laboratory of clinical immunology,
Ivanovo
Russian FederationD. L. Voskresenskaya
Federal State Budget Establishment “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova” of the Ministry of Health of Russia
Email: fake@neicon.ru
Student,
Ivanovo
Russian FederationReferences
- Morikawa M., Derynck R., Miyazono K. TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016, 8, pii: a021873.
- Chegini N. Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder. Semin Reprod Med. 2010, 28 (3), 180–203.
- Lee B. S., Nowak R. A. Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta. J Clin Endocrinol Metab. 2001, 86 (2), 913–920.
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