THE ROLE OF PREGNANCY-SPECITIC GLYCOPROTEIN IN THE REGULATION OF PRODUCTION OF KEY CYTOKINES THAT DETERMINE BALANCE Th1 / Th2

S. A. Zamorina; Заморина С. А.; L. S. Litvinova; Литвинова Л. С.; K. A. Yurova; Юрова К. А.; O. G. Khaziakhmatova; Хазиахматова О. Г.; V. P. Timganova; Тимганова В. П.; M. S. Bochkova; Бочкова М. С.; P. V. Khramtsov; Храмцов П. В.; M. B. Rayev; Раев М. Б.

THE ROLE OF PREGNANCY-SPECITIC GLYCOPROTEIN IN THE REGULATION OF PRODUCTION OF KEY CYTOKINES THAT DETERMINE BALANCE Th1 / Th2

Authors: Zamorina S.A.¹^,2, Litvinova L.S.³, Yurova K.A.³, Khaziakhmatova O.G.³, Timganova V.P.¹, Bochkova M.S.¹, Khramtsov P.V.², Rayev M.B.¹^,2
Affiliations:
1. Institute of Ecology and Genetics of Microorganisms UB RAS
2. Perm State National Research University
3. Immanuel Kant Baltic Federal University
Issue: Vol 20, No 2 (2017)
Pages: 129-131
Section: Articles
Submitted: 22.10.2020
Published: 15.04.2017
URL: https://rusimmun.ru/jour/article/view/601
ID: 601

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Abstract

The effect of pregnancy-specific glycoprotein (PSG) on the production of Th1/Th2-cytokines by intact mononuclear cells and monocultures of CD4 cells under in vitro conditions by flow-through fluorimetry was studied. It has been established that PSG predominantly suppresses the production of Th1-cytokines (IFN-γ, TNF-α, IL-2) by the types of cells studied, and it regulates the production of Th2-cytokines in different directions, decreasing the production of IL-9, IL-13, IL-6, but increasing the level of IL-5. As a result, PSG forms the integral Th2-cytokine profile of intact peripheral cells of the immune system.

Keywords

трофобластический β1-гликопротеин (ТБГ), беременность, Th1-цитокины, Th2-цитокины, лимфоциты, моноциты, CD4-лимфоциты, β1-trofoblastic glycoprotein (TBG), pregnancy, Th1-cytokins, Th2-cytokins, lymphocytes, monocytes, CD4 lymphocytes

References

Wegmann T. G., Lin T. H., Guilbert L., Mosmann T. R. // Immunol. Today. 1993. V.14, № 7. Р. 353-356.
Saito S., Nakashima A., Shima T., Ito M. // Amer.J. Reprod. Immunol. 2010. V. 601. № 63. P. 601-610.
Раев М. Б. Cпособ выделения и очистки трофобластического β-1-гликопротеина. Патент РФ № 2367449 от 20.09.2009. / Раев М. Б.// «Изобретения. Полезные модели». 2009. № 26.

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THE ROLE OF PREGNANCY-SPECITIC GLYCOPROTEIN IN THE REGULATION OF PRODUCTION OF KEY CYTOKINES THAT DETERMINE BALANCE Th1 / Th2

Full Text

Abstract

Keywords

About the authors

References

Supplementary files

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