Email this article ALLERGIC DISEASES AND HELICOBACTER PYLORI INFECTION PART 2. sIgE MUCOSAL IMMUNE RESPONSE TO H. PYLORI
- Authors: Gervazieva V.B.1, Mazurina S.A.1, Ilintseva N.V.1, Sveranovskaya V.V.1
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Affiliations:
- I. Mechnikov Research Institute of Vaccines & Sera
- Issue: Vol 20, No 2 (2017)
- Pages: 278-280
- Section: Articles
- URL: https://rusimmun.ru/jour/article/view/654
- ID: 654
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Abstract
The levels of sIgA, CagA, IL-17, sIgE-to H.pylori and to CagA have been analyzed by ELISA in the samples of coprofiltrates, taken from children with allergy and concomitant gastrointestinal diseases. Anti-H. pylori and anti-CagA sIgE have been elevated in groups of patients with allergic diseases in combination with chronic gastroduodenitis and among children with erosive and ulcerous leisons, being the most significant among the last group. Non-allergic patients with chronic gastroduodenitis were characterized by the highest concentration of IL-17 and sIgA, which was associated with the confirmed H.pylori infection. Our data demonstrates that sIgE to H.pylori, together with sIgA, represent a part of protective mechanisms during the H.pylori -assosiated gastrointestinal pathology.
About the authors
V. B. Gervazieva
I. Mechnikov Research Institute of Vaccines & Sera
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
S. A. Mazurina
I. Mechnikov Research Institute of Vaccines & Sera
Email: noemail@neicon.ru
Russian Federation
N. V. Ilintseva
I. Mechnikov Research Institute of Vaccines & Sera
Email: noemail@neicon.ru
Russian Federation
V. V. Sveranovskaya
I. Mechnikov Research Institute of Vaccines & Sera
Email: noemail@neicon.ru
Russian Federation
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).