Email this article STUDY OF THE BIOLOGICAL AND MECHANICAL PROPERTIES OF THE ULTRA-HIGH-MOLECULAR-WEIGHT-POLY-ETHYLENE COMPOSITE FOR EMPLOYMENT AS CARTILAGE BIOIMPLANT
- Authors: Kiselevsky M.V.1, Anisimova N.Y.1, Lebedinskaya O.V.2, Kopylov A.N.1
-
Affiliations:
- NN Blokhin Scientifi c Institutе “Russian Cancer Research Center”
- Acad. EA Wagner Perm State Medical University
- Issue: Vol 20, No 2 (2017)
- Pages: 347-350
- Section: Articles
- Submitted: 22.10.2020
- Published: 15.04.2017
- URL: https://rusimmun.ru/jour/article/view/682
- ID: 682
Cite item
Full Text
Abstract
Aim of this study is researching the biological and mechanical features of the material, made of ultra-high-molecular-weight-poly-ethylene(UHMWPE) Studing the mechanical features showed that the material prepared with addition of Al2O3 and with using mechanical activation has the highest mechanical features, wear resistance in particular, in comparison with UHMWPE samples without Al2O3 or prepared without mechanical activation. was chosen for. After 60 days orthotopical transplantation this material in rats we did not fined signs of inflammation, cellular infiltration, destruction of material or bone-cartilage defect. Sample was in position of implantation without any shifts. Acquired data shows the perspective-ness of UHMWPE as a material for creating bioimplants for cartilage defects replacement.
About the authors
M. V. Kiselevsky
NN Blokhin Scientifi c Institutе “Russian Cancer Research Center”
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
N. Yu. Anisimova
NN Blokhin Scientifi c Institutе “Russian Cancer Research Center”
Email: noemail@neicon.ru
Russian Federation
O. V. Lebedinskaya
Acad. EA Wagner Perm State Medical University
Email: noemail@neicon.ru
Russian Federation
A. N. Kopylov
NN Blokhin Scientifi c Institutе “Russian Cancer Research Center”
Email: noemail@neicon.ru
Russian Federation
References
- Bobic V. Articular cartilage - to repair or not to repair / Bobic V., Noble J. // British Editorial Society of Bone and Joint Surgery J Bone Joint Surg [Br].-2000-82 - P. 165-166.
- Perera J. The present state of treatments for articular cartilage defects in the knee / Perera J., Gikas P., Bentley G. // Annals of The Royal College of Surgeons of England.- 2012-94.- P. 381-387.
- Curl W. Cartilage injuries: a review of 31,516 knee arthroscopies / Curl W., Krome J., Gordon E. // Arthroscopy.- 1997-13 - P. 456-460.
- Simon C. Functional articular cartilage repair: here, near, or is the best approach not yet clear? / Simon C., Daniёl B., Saris and Floris P. // Journal Nature Reviews Rheumatology- 2013-9 - P. 277-290.
- Redman S. Current strategies for articular cartilage repair / Redman S., Oldfield S. and Archer C. // Eur. Cell Mater.- 2005.- 9 - P. 23-32.
- Repair of defects in articular joints / Lynn A., Brooks R., Bonfield W., Rushton N. // J Bone Joint Surg Br.- 2004-86 - P. 1093-1099.
- UHMWPE biomaterials handbook Steven M. Kurz - 2009.
- Исследование биосовместимости и иммуногенности синтетических имплантатов / Копылов А. Н., Лебединская О. В., Анисимова Н. Ю., Сенатов Ф. С., Максимкин А. В., Киселевский М. В. // Российский иммунологический журнал.-2013.- Т. 7.- № 2-3.- С. 304-305.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).