CD57 expression by peripheral blood cytotoxic T cells in sarcoidosis

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Abstract

Using 10-color fl ow cytometry we characterized cytotoxic T cell subsets based on expression of CD45RA, CD62L, CD27, and CD28 and compared the expression of CD57 between these subsets in peripheral blood sample from patients with chronic sarcoidosis (n=46) and healthy volunteers (n=46). Circulating naive, central and eff ector memory as well as TEMRA CD3+CD8+ cells of sarcoidosis patients contained signifi cantly increased proportions CD57+ cells when compared with healthy controls. Interestingly, CD57 expression was increased in subsets with ‘non mature’ and intermediate phenotypes – EM1, EM2, EM4, pE1 and pE2. Our results indicate the involvement of CD3+CD8+ in maintenance in sarcoidosis as well as suggest CD57-positive cells to be the novel target for evaluation the eff ectiveness of sarcoidosis therapy.

About the authors

I. . Kudryavtsev

Academician I. P. Pavlov First St. Petersburg State Medical University; Institute of Experimental Medicine

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

N. . Lazareva

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: noemail@neicon.ru
Russian Federation

O. . Baranova

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: noemail@neicon.ru
Russian Federation

M. . Serebriakova

Institute of Experimental Medicine

Email: noemail@neicon.ru
Russian Federation

T. . Ses’

Academician I.P. Pavlov First St. Petersburg State Medical University; State Research Institute of Highly Pure Biopreparations

Email: noemail@neicon.ru
Russian Federation

M. . Ilkovich

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: noemail@neicon.ru
Russian Federation

A. . Totolyan

Academician I.P. Pavlov First St. Petersburg State Medical University; St. Petersburg Pasteur Institute,

Email: noemail@neicon.ru
Russian Federation

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