Email this article Study of migration of nano-dimensional metallic particles in the composition of supernatants on the model of inbreed mobiles BALB-CJ
- Authors: Labis V..1, Bazikyan E..1, Manskih V..2, Sizova S..3, Khaidukov S..3, Kozlov I..4
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Affiliations:
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- The Institute of Mitoengineering of Lomonosov Moscow State University
- Institute of Bioorganic Chemistry named by Academicians M.M. Shemyakin and Y.A. Ovchinnikov
- FNKTS children’s hematology, oncology and immunology D. Rogachev
- Issue: Vol 21, No 3 (2018)
- Pages: 342-347
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/891
- DOI: https://doi.org/10.31857/S102872210002407-2
- ID: 891
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Abstract
The purpose of this study was to investigate the ability of migration into the immunocompetent organs of nanoscale metal particles in the composition of supernatants. The goal is to model peritonitis, with intraperitoneal administration of solutions, in particular, with induction and without induction by lipopolysaccharide. Nanoscale metal particles were obtained in the laboratory from the surface of the dental implants “Nobel Biocare” and “Alpha BiO” in the composition of supernatants. In the experiment, 12 inbred mice, divided conditionally into 3 groups were injected with solutions: antibiotic, nanoscale particles obtained from two systems of dental implants in supernatants. On day 10 three organs were examined: the liver, kidney and spleen. A histological study indicated the presence of Al2O3, nanoparticles, found on the boundary between white and red pulp inside macrophages in the group injected with supernatants taken from «Alpha BIO» surface.
About the authors
V. . Labis
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
E. . Bazikyan
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: noemail@neicon.ru
Russian Federation
V. . Manskih
The Institute of Mitoengineering of Lomonosov Moscow State University
Email: noemail@neicon.ru
Russian Federation
S. . Sizova
Institute of Bioorganic Chemistry named by Academicians M.M. Shemyakin and Y.A. Ovchinnikov
Email: noemail@neicon.ru
Russian Federation
S. . Khaidukov
Institute of Bioorganic Chemistry named by Academicians M.M. Shemyakin and Y.A. Ovchinnikov
Email: noemail@neicon.ru
Russian Federation
I. . Kozlov
FNKTS children’s hematology, oncology and immunology D. Rogachev
Email: noemail@neicon.ru
Russian Federation
References
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- Лабис В. В., Базикян Э. А., Козлов И. Г., Сизова С. В., Хайдуков С. В. Наноразмерные частицы – участники остеоинтеграции // Бюллетень Оренбургского научного центра УрО РАН. 2016. 1: 1–18. [Labis V. V. Bazikyan E. A., Kozlov I. G., Sizova S. V., Hajdukov S. V. Nanosized particles – participants of osseointrgration. Bulletin of Orenburg scientifi c center of UrB RAS, 2016. 1: 1–18. (URL: http://elmag.uran.ru:9673/magazine/Numbers/2016–1/Articles/LVV-2016–1.pdf)]
- Лабис В. В., Базикян Э. А., Сизова С. В., Хайдуков С. В., Козлов И. Г. Исследование наноразмерных частиц, полученных в супернатантах с дентальных имплантатов двух систем А и В // Бюллетень Оренбургского научного центра УрО РАН. 2016. 2: 16с. [Labis V. V. Bazikyan E. A., Sizova S. V., Hajdukov S. V., Kozlov I. G. Nanosized particles obtained in supernatanes from dental implants of systems A and B // Bulletin of Orenburg scientifi c center of UrB RAS, 2016. 1: 1–18. (URL: http://elmag.uran.ru:9673/magazine/Numbers/2016–2/Articles/VVL-2016–2.pdf)]/
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).